Research Mission 
The aims of our efforts are to elucidate the science of nutrient-responsive sensing and signaling processes in human systems and to rationally apply this knowledge in development of effective interventions. We apply three approaches in these endeavors; namely:
- Integrative omics to:
a) characterize and catalog structural chemistry and molecular dynamics of nutrient-responsive human systems (receptors, transporters, enzymes and hormones)
b) determine functional implications of structural variation in elements of these systems - Physiological optics to characterize in vivo human response to nutrient intake (tissue status change and retinal/visual function)
- Ultra-structural/membrane/organoid biophysics to identify modifiable (‘druggable’) mechanisms and rate-limiting steps of nutrient sensing and signaling in human retina and brain